Aromatase inhibition by bioavailable methylated flavones
نویسندگان
چکیده
منابع مشابه
Mechanism of CYP2C9 inhibition by flavones and flavonols.
This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin). With the exception of flavone, all flavonoids were shown to inhibit CYP2...
متن کاملAromatase inhibition and inactivation.
Aromatase is the key enzyme in the synthesis of estrogens and mediates the conversion of androstenedione and testosterone to estrone and estradiol. Because of the importance of estrogen in stimulating breast cancers, the inhibition of estrogen synthesis is a logical approach to treatment. Aromatase is an excellent target for inhibition, because it is the last step in steroid biosynthesis, and, ...
متن کاملBifunctional effects of O-methylated flavones from Scutellaria baicalensis Georgi on melanocytes: Inhibition of melanin production and intracellular melanosome transport
The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect on melanogenesis; (2) wogonin and its glycosi...
متن کاملAromatase Inhibition and Inactivation
I n t r o d u c t i o n Aromatase is the key enzyme in the synthesis of estrogens and catalyzes the conversion of androstenedione and testosterone into estrone and estradiol. Estrogens are known to be important in the growth of breast cancers in both preand postmenopausal women. In premenopausal women, the ovarian granulosa cells are the major sites of estrogen synthesis. Aromatization also occ...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2007
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2007.01.006